Ctcf and ctcfl in cancer

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August undefined, 2024

WebMar 3, 2024 · An expanding literature describes a cancer-associated role for BRD8 (reviewed in (Fujisawa and Filippakopoulos, ... Since BRD8 is not predicted to bind directly to DNA, an association with CTCF/CTCFL could be an effective route to achieving chromatin proximity (Pena-Hernandez, Marques, Hilmi et al., 2015). To further explore … WebSep 15, 2024 · Specific CTCF binding events occur in human cancers. Cancer-specific CTCF binding can be induced by other transcription factors to regulate oncogenic gene …

CTCF and CTCFL in cancer Request PDF - ResearchGate

WebApr 1, 2024 · CTCF and CTCFL in cancer. CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), … WebApr 18, 2024 · In cancer, CTCF binding is disrupted through various mechanisms, such as DNA copy number alterations spanning domain boundaries 13, microdeletions within CBSs 13, and hypermethylation of CBSs 14 ... culver city oral surgeon

Pan-cancer analysis and experimental validation of DTL as a …

WebCCCTC-binding factor ( CTCF ), an 11- zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive … WebResearch to identify CTCFL as a biomarker for specific cancer types and for therapeutical approaches has been followed up . With the advent of next-generation-sequencing many advances in the field of DNA binding factors have been made. ... CTCF/CTCFL co-bound and CTCF or CTCFL stand-alone sites) and the average CTCF site as reference were ... WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … east of here penzance

Defining the relative and combined contribution of CTCF and CTCFL to …

WebCTCF-mediated enhancer blocking is conserved from Drosophila to man (Moon et al. 2005) Antisense transcription of triplet repeats is constrained by CTCF (Cho et al. 2005) Boundaries between X inactivation and escape of inactivation bind CTCF (Filippova et al. 2005) CTCF antagonizes with CTCFL at the cancer testis gene MAGE-A1 (Vatolin et al. … WebJun 23, 2024 · The past and present efforts to combine CTCF studies with CTCFL/BORIS research are designed to emphasize Normal and … east of here rugsWebApr 22, 2024 · Search life-sciences literature (41,693,946 articles, preprints and more) Search culver city optimum

"WebCancer; Cell Biology; Stem Cells & Development; Metabolic & Cardiovascular Disease; ... 我们为您找到 ctcf 的 1 个相关产品结果。 ... Synonyms: CTCFL;BORIS;CT27;CTCF-T;HMGB1L1;dJ579F20.2. Type: Rabbit Polyclonal Antibody (1) 加入对比（最多5 ... " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

WebMar 20, 2024 · As CTCF is a significantly mutated gene in endometrial cancer, we sequenced CTCF in five endometrial cancer cell lines and identified four mutations (Figures 1a and c). WebCancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means ... that DTL interacted with arsenic trioxide, aflatoxin b1, MLN7243 and palmitic acid. In addition, NRF1, E2F4, STAT3, CTCF, CTCFL and E2F1 were predicted to be the interacting targets. Hsa-miR-330-3p, hsa-miR ...

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WebCTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes. ... BORIS like protein; BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CCCTC-binding factor like; CT27; CTCF paralog; CTCF T; … WebFeb 16, 2024 · CTCF overexpression has been identified in breast cancer , cervical cancer , ovarian cancer , and hepatocellular carcinoma . Some mutations are related to tumors ( 15 ). In particular, hotspot binding site mutations occur at quite a high frequency (25%) in GC, and these mutations are associated with alterations in gene expression ( 16 ).

WebSep 15, 2024 · Identification of cancer-specific CTCF binding patterns in the human genome. a Distribution of coefficient of variation of chromatin accessibility at different genomic features, calculated using DNase-seq data from over 60 cell lines from ENCODE.b Distribution of occupancy score for all 688,429 union CTCF binding sites (blue), and … WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is …

WebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... WebApr 10, 2024 · Pan-cancer bioinformatics analysis showed that the expression of DTL was correlated with the prognosis, immunotherapy, and clinical indexes in various cancers. ... NRF1, E2F4, STA T3, CTCF, CTCFL ...

WebJun 15, 2005 · Abstract. CTCF is a candidate tumor suppressor gene encoding a multifunctional transcription factor. Surprisingly for a tumor suppressor, the levels of CTCF in breast cancer cell lines and tumors were found elevated compared with breast cell lines with finite life span and normal breast tissues. In this study, we aimed to investigate the …

culver city orange theoryWebSep 15, 2024 · Background: The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome … culvercity.org building safetyWebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of … culver city orgWebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, … east of hollywood bandWebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … east of hounslow by khurrum rahmanWebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... culver city orchestraWebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. A positive correlation has been … east of india christening gifts