Fip200是什么蛋白
WebOct 5, 2024 · 在ei24耗尽的细胞中，胞质er表面持续的ca2+ 瞬变/振荡导致fip200自噬体启动复合体在er上积累。这种缺陷被衰减的er ca2+ 瞬变抑制。多模态sim分析显示，er上的ca2+ 瞬变触发了动态和易融合的液体样fip200点阵的形成。 WebmTOR信号通路[2] mTORC1促进细胞生长的过程主要由生长因子、能量状态、含氧量和氨基酸等多种信号调节。参与调节mTORC1活性的最重要蛋白质是结节性硬化症复合 …
Fip200是什么蛋白
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National Center for Biotechnology Information WebRecent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development.
WebApr 28, 2008 · FIP200 is required for membrane targeting and proper function of ULK. (A) FIP200 +/− and FIP200 −/− MEFs stably expressing GFP-ULK1 or -ULK2 were cultured in starvation medium for 120 min. The cells were fixed and examined by fluorescence microscopy. Bar, 20 μm. (B) FIP200 +/+ and FIP200 −/− MEFs were cultured in complete … WebMar 16, 2024 · These functions of TNIP1 depend on an evolutionarily conserved LIR motif as well as an AHD3 domain, which are required for binding to the LC3/GABARAP family of proteins and the autophagy receptor TAX1BP1, respectively. We further show that phosphorylation appears to regulate its association with the ULK1 complex member …
WebAug 10, 2024 · FIP200 and NDP52 samples for HDX were concentrated to a 20 μM stock solution, ULK1 complex was concentrated to a 10 μM stock solution, while POPS/POPI … WebMonoclonal Antibody for studying RB1CC1. Cited in 62 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FIP200 …
WebDec 7, 2015 · Autophagy is a major intracellular degradation system by which cytoplasmic components are enclosed by autophagosomes and delivered to lysosomes. Formation of the autophagosome requires a set of autophagy-related (Atg) proteins. Among these proteins, the ULK1 complex, which is composed of ULK1 (or ULK2), FIP200, Atg13, and Atg101, … the va way is comprised of four areasWebMar 27, 2024 · 在一些选择性自噬过程中，自噬受体蛋白可通过结合ULK复合物中的FIP200亚基来招募和激活ULK复合物，并在自噬底物附近原位（in situ）介导自噬前体的形成。. 但是，目前自噬受体蛋白通过结合FIP200来招募ULK复合物的分子机理和相关的调控机制仍然未 … the va websiteWebApr 18, 2024 · FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites, but only in their combined presence does xenophagy proceed. Such recruitment of the upstream autophagy machinery by NDP52 reveals how detection of cargo-associated "eat me" … the va whole health systemWebNov 23, 2024 · K562 wild-type (WT) and FIP200 KO cells expressing tf-NBR1 or tf-LC3 were nucleofected with TagBFP or TagBFP-FIP200 and analyzed for red:green ratio and BFP expression at 8 h post-nucleofection. Median values for each sample are identified by a black line within each violin. The red dotted line corresponds to the red:green ratio of … the va wikiWebJul 25, 2005 · FIP200 is also identified by Chano et al. (2002a) independently as a potential regulator of the RB1 gene (designated by this group as RB1CC1 for RB1-inducible coiled … the va wizardWebFeb 18, 2024 · The binding of Atg13 stabilizes and activates ULK and facilitates the phosphorylation of FIP200 by ULK, whereas knockdown of Atg13 inhibits autophagosome formation. Inhibition of mTOR by rapamycin or leucine deprivation, the conditions that induce autophagy, leads to dephosphorylation of ULK1, ULK2, and Atg13 and activates ULK to … the va wichita ksWebJun 22, 2024 · 在小鼠中敲除或突变自噬相关蛋白 fip200 有效抑制自噬和乳腺癌发生 首先就是要看一下自噬和乳腺癌的发生到底是什么关系。 这里作者针对FIP200（又 … the va\\u0027s mission statement