Labs to monitor with daptomycin

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August undefined, 2024

WebJan 1, 2024 · Daptomycin for injection is indicated for the treatment of adult patients with Staphylococcus aureus bloodstream infections (bacteremia), including adult patients with right-sided infective endocarditis, caused by methicillin-susceptible and … WebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of …

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WebDaptomycin (Cubicin®) for the treatment of Staphylococcus aureus bacteraemia (SAB) when associated with right-sided infective endocarditis or with complicated skin and soft … WebNational Center for Biotechnology Information fncs pokal

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WebDaptomycin pharmacokinetics were generally linear and time-independent at doses of 4 to 12 mg/kg q24h. Steady-state trough concentrations were achieved by the third daily dose. The mean (SD) steady-state trough concentrations attained following administration of … WebMonitoring Requirements: CPK levels should be monitored weekly. Daptomycin should be discontinued in patients with unexplained signs and symptoms of myopathy in conjuction … Webthe patient was initiated on daptomycin 6 mg/kg (300 mg) daily in response to wound cultures detecting Enterococcus faecium susceptible only to daptomycin and linezolid. Starting 96 hours after daptomycin initiation, there was a profound reduction in the patient’s WBC, reaching a nadir of 1.63 x 10-3 /µL after 12 days of therapy. Prior to ... fncsn

Effect of Statin Coadministration on the Risk of Daptomycin

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WebThe pharmacokinetic/pharmacodynamic indices that correlate with Daptomycin activity are the ratios of C max to MIC and 24-hour AUC to MIC. Administration of once daily dose of … WebTherapeutic Drug Monitoring of Daptomycin: A Retrospective Monocentric Analysis. Daptomycin plasma concentrations are often unpredictable as shown by highly variable … fncs mapWebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp . fncs maps

"WebMar 10, 2024 · Daptomycin exposures are higher in healthy geriatric adults than in healthy young adults; however, daptomycin dosage adjustments not needed in geriatric patients … " - Labs to monitor with daptomycin

Labs to monitor with daptomycin

WebJun 17, 2024 · the daptomycin MIC was 4 mg/L in ~ 70% of patients.3,4 Studies have also shown that high-dose daptomycin is generally well-tolerated and safe. It is recommended to monitor creatine kinase (CK) weekly in all patients receiving daptomycin.5 Recommendations Daptomycin MIC (mg/L) breakpoints for Enterococcus faecium1 … WebDaptomycin Sample type: Serum Test name: Daptomycin Condition / Indication: Requesters have found these assays to be of value in patients with difficult infections and/or impaired renal function. Advance warning: Not normally required during our core working hours (Mon – Fri 09:00 – 17:15).

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WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, … WebNov 23, 2024 · Daptomycin is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream. …

WebYour doctor may order certain lab tests to check your body's response to daptomycin injection. Before having any laboratory test, tell your doctor and the laboratory personnel … WebJul 1, 2013 · References (1) Interaction of daptomycin with two recombinant thromboplastin reagents leads to falsely prolonged patient prothrombin time/International Normalized Ratio results. Article. Feb 2008 ...

WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for … WebNov 23, 2024 · Usual Pediatric Dose for Skin and Structure Infection. 1 to less than 2 years: 10 mg/kg IV every 24 hours. 2 to 6 years: 9 mg/kg IV every 24 hours. 7 to 11 years: 7 mg/kg IV every 24 hours. 12 to 17 years: 5 mg/kg IV every 24 hours. Duration of therapy: Up to 14 days. Use: For the treatment of cSSSI due to susceptible isolates of S aureus ...

Webpathogens and to determine their susceptibility to daptomycin. To reduce the development of drugresistant bacteria and maintain the effectiveness of CUBICIN and other …

WebJun 15, 2010 · More frequent monitoring is also recommended in the product label for daptomycin for patients receiving prior or concomitant therapy with a b-hydroxy-b-methylglutaryl- coenzyme A reductase inhibitor or those with renal insufficiency [ 19 ]. fncs memesWebJun 6, 2024 · Drug/laboratory test interactions. False prolongation of prothrombin time (PT) and elevation of international normalised ratio (INR) have been observed when certain recombinant thromboplastin reagents are utilised for the assay (see section 4.5). ... before commencing therapy with daptomycin. Regular monitoring of renal function is advised … fncs royalWebGeneric Name Daptomycin DrugBank Accession Number DB00080 Background. Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE). 7,8,21 Chemically, … fncsrm kolonhttp://antimicrobe.org/drugpopup/daptomycin.htm fncs naeWebdactinomycin (Rx) Brand and Other Names: Cosmegen Classes: Antineoplastics, Antibiotic Dosing & Uses AdultPediatric Dosage Forms & Strengths 500mcg/vial Wilms Tumor Indicated for Wilms tumor as... fncss fncs regelnWebSep 6, 2024 · Renal Dosing. Patients with Renal Impairment: Daptomycin is eliminated primarily by the kidneys; therefore, a modification of CUBICIN dosage is recommended for … fn csr-20