Teneligliptin impurity a
Web9 Aug 2016 · Teneligliptin is a novel drug, which is used for the treatment of type 2 diabetes mellitus. It is an antidiabetic drug that belongs to dipeptidyl peptidase-4 inhibitors or “gliptins” (Kishimoto 2013 ). Chemically, it is { (2S, 4S)-4- [4- (3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl} (1, 3-thiazolidin-3-yl) methanone (Fig. 1 ). WebThe retention time of Teneligliptin, Impurity B and Impurity G were 7.443 min, 6.650 min and 8.473 min respectively. Linearity for Teneligliptin, Impurity B and Impurity G were found in the range ...
Teneligliptin impurity a
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WebResults: The % recovery of teneligliptin and metformin HCL observed was above 90% from LOQ level to 150%. The correlation coecient r 2 was 0.999 for metformin HCl, teneligliptin, … WebTeneligliptin Impurity F DiHCl. Synonym (2S,4S)-N-(2-mercaptoethyl)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidine-2-carboxamide dihydrochloride. Molecular Formula. C 2 1 H 3 0 N 6 OS. 2 HCl. Molecular Weight 414.58 2 36.46. Catalogue Number AR-T01434. Parent Drug TENELIGLIPTIN.
WebTeneligliptin Impurity 14. CAS No. 401566-80-1. C 27 H 38 N 6 O 3 S. M.W. 526.70. TLC Pharmaceutical Standards Ltd. Phone: (905)-898-3645; Sales: (647)-699-8592; Fax: (905)-898-0595; E-mail: [email protected]; 130 Pony Drive Newmarket, Ontario, Canada, L3Y 7B6. Sales and Customer Services for Mainland China Web28 Oct 2024 · An accurate, precise and robust analytical method was developed for the impurity profiling in the metformin hydrochloride and teneligliptin hydrobromide hydrate tablet. The gradient was optimized for better separation of impurities by using BDS Hypersil C18 250 × 4.6 mm, 5µ column operated at 35 °C. The octane sulfonic acid and phosphate …
WebTeneligliptin Boc Acid Impurity Or (4S)-1- (tert-butoxycarbonyl)-4- (4- (3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidine-2-carboxylic acid, Teneligliptin Boc Acid is an … Web1 Dec 2024 · Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage …
Web16 May 2024 · A 0.01 per cent w/v solution of each of impurity A RS, impurity B RS and impurity C RS in the solvent mixture. Reference solution (b). Weigh and transfer about 50 mg of teneligliptin hydrobromide hydrate RS to a 50- ml volumetric flask, add 5.0 ml of reference solution (a), dissolve and dilute to volume with the solvent mixture.
WebTeneligliptin is an anti-diabetic drug used to treat Diabetes mellitus Type II and three unknown impurities were detected in Teneligliptin bulk drug substance using RP-UFLC method at RT 4.02 min, 5.09 min and 6.2 min. These impurities were isolated by preparative HPLC and further characterized by using LC-MS/MS and NMR techniques. inclusion\\u0027s 21Web27 Oct 2024 · The analytes were detected in the positive mode using multiple reaction monitoring (teneligliptin: m/z 427.2→243.1; teneligliptin-d 8: m/z 435.2→251.3; teneligliptin sulfoxide: m/z 443.2→68.2). The method demonstrated accuracy, precision, and linearity over the concentration range of 5 to 1000 ng/mL for teneligliptin and 2.5 to 500 ng/mL ... inclusion\\u0027s 1wWebTeneligliptin belongs to the dipeptidyl peptidase-4 inhibitors class of drugs. This anti-diabetic drug is used for the treatment of type 2 diabetes mellitus. Reference standards of … inclusion\\u0027s 1vWebTeneligliptin Impurity B (CAS No: 401566-80-1) Or tert-butyl (2S,4S)-4- (4- (3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-2- (thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate, … inclusion\\u0027s 1zWeb15 Aug 2024 · Linearity for Teneligliptin, Impurity B and Impurity G were found in the range of 500-3000 µg/ml (R2 = 0.998), 5-15 µg/ml (R2 = 0.994) and 5-15 µg/ml (R2 = 0.998) respectively. The accuracy... inclusion\\u0027s 27WebTeneligliptin also reduces plasma triglyceride levels by consistently increasing GLP-1 levels. The current study shows that teneretine is a potent, competitive, and long-acting DPP-4 … inclusion\\u0027s 24WebTeneligliptin hydrobromide hydrate is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 inhibitors are ... Impurity Related substances that may be present in teneligliptin hydrobromide hydrate are listed in dossier. Specification The drug substance specification including control of identity, purity, and other general test has been ... inclusion\\u0027s 20